High school student Jane Shipley seeks to mend her splintering relationship with childhood best friend Merritt, and fit in with her rebellious peers. When Jane's math teacher oversteps his bounds, an apathetic high school administration forces Jane and Merritt to take matters into their own hands, driving their relationship into further turmoil and inciting deadly consequences....

该剧主要讲述四个家境、性格、目标全然不同的大一女生，因寝室奇缺，而被安排进了有着霉气怨气聚集地之称的梅苑438寝室，于是便产生了这系列或惊奇或喜剧或温馨或纠结的校园故事！最终四人建立起深厚友谊并得到了蜕变和成长。